学院（School）:第二临床医学院

The Second School of Medicine

专业（Discipline）:

骨科学 Orthopedic

研究方向（Research Interests）:

1.椎间盘退变 Intervertebral disc degeneration

2.微创生物治疗技术 Minimally Invasive Biological Therapy

邮箱（Email）:

aiminwu@wmu.edu.cn

个人简历（Biography）

教育背景(Educational Background)

本人博士毕业于温州医科大学，在上海交通大学医学院完成博士后工作。先后访学美国马里兰大学、哈佛大学、香港大学骨科学系、英国皇家骨科医院。

I graduated from Wenzhou Medical University with a PhD degree, and completed my postdoctoral work at Shanghai Jiao Tong University School of Medicine. Finish my research fellow at the University of Maryland, Harvard University, the Department of Orthopaedic Surgery of the University of Hong Kong, and the Royal Orthopaedic Hospital in the UK.

工作经历(Working Experience)

温州医科大学附属第二医院脊柱外科 教授 副主任医师，博导，博士后合作导师

温州医科大学附属第二医院、育英儿童医院副院长

Spine Surgeon，professor, deputy chief physician, doctoral supervisor, postdoctoral co-supervisor, Vice President the Second Affiliated Hospital of Wenzhou Medical University and Yuying Children's Hospital, engaging in the spine department.

学术兼职(Part-time Academic Jobs)

兼任国际矫形与创伤外科学会（SICOT）中国部青年委员会常委，微创及脊柱外科专委会委员，中国康复医学会脊柱脊髓专业委员会数字脊柱外科学组委员，浙江省医师协会青年医师分会副会长，浙江省康复医学会脊柱脊髓专业委员会委员，AOSpine青年讲师，华人国际骨研学会终身会员，中国骨科菁英会（脊柱专业）委员等。任BMC Surgery杂志 Senior Editor；BMC Musculoskeletal Disorders, Asian Spine Journal，Journal of Spine Surgery 杂志 Editorial Board；Age and Disease，BMT杂志Youth Editorial Board。

member of the Standing Committee of the Chinese Section of Societe Intemationale de Chirurgie Orthopedique et de Traumatologie (SICOT), member of the Minimally Invasive and Spinal Surgery Committee, member of the Digital Spine Surgery Group of the Chinese Society of Rehabilitation Medicine Spinal Cord Speciality Committee, vice-chairman of the Young Physicians Branch of the Zhejiang Medical Doctors' Association, member of the Zhejiang Society of Rehabilitation Medicine Spinal Cord Speciality Committee, young instructor of AOSpine,

lifetime member of the Chinese International Orthopaedic Research Society, member of the Chinese Orthopaedic Elite Society (spinal specialty). Senior Editor of BMC Surgery; Editorial Board of BMC Musculoskeletal Disorders, Asian Spine Journal, Journal of Spine Surgery; Youth Editorial Board of Age and Disease, BMT. Age and Disease, BMT, Youth Editorial Board.

所获荣誉(Awards)

以第一作者或通讯作者身份在国际知名期刊上发表了60余篇英文论文，涵盖基础转化研究(如Lancet Rheumatology, The Lancet Healthy Longevity, Advanced Functional Materials, ACS Nano, Bioactive Materials, Bone Research, Adv Science, Small, Exp Mol Med)和临床研究(包括Pain, Journal of Bone and Mineral Research, Bone & Joint Journal, Spine, Spine J，Eur Spine J)。已授权第一发明人发明专利美国2项，中国7项，其中已经成功转化2项。据Google Scholar数据，本人论文已被引超20000次，H指数达到48。

先后入选浙江省医药卫生高层次人才-创新人才和医坛新秀,温州市“551”人才等，爱思唯尔发表2023、2024年全球前2%Top科学家名单。承担国家自然科学基金3项，浙江省杰出青年基金等。研究成果获第二完成人获浙江省科技进步奖二等奖，浙江省医药卫生科技奖一等奖，第三完成人获山东省医学奖一等奖，第七完成人获上海市医学科技奖二等奖。 Have published more than 60 papers in English as first or corresponding author in international journals covering basic translational research (e.g. Lancet Rheumatology, The Lancet Healthy Longevity, Advanced Functional Materials, ACS Nano, Bioactive Materials, Bone Research, Adv Science, Small, Exp Mol Med. Bioactive Materials, Bone Research, Adv Science, Small, Exp Mol Med) and clinical research (including Pain, Journal of Bone and Mineral Research, Bone & Joint Journal, Spine, Spine J, Eur Spine, Spine J, Eur Spine). Spine J, Eur Spine J). Have been granted 2 patents in the US and 7 patents in China as the first inventor, of which 2 have been successfully translated. According to Google Scholar data, the papers have been cited more than 20,000 times, with an H-index of 48. Have been selected as one of the high-level talents in medicine and health in Zhejiang Province, as well as one of the ‘551’ talents in Wenzhou City, etc. Elsevier top 2% Top Scientists in the world for the years of 2023 and 2024. Granted 3 National Natural Science Foundation of China project, awarded the second prize of Zhejiang Provincial Science and Technology Progress Award for the second completer, the first prize of Zhejiang Provincial Medicine and Health Science and Technology Award for the third completer, the first prize of Shandong Provincial Medicine Award for the third completer, and the second prize of Shanghai Medical Science and Technology Award for the seventh completer.

发表文章（Representative Publication）

[1] Wu A#, Cross M#, Elliott JM*……... Ong KL, Vos T, March LM. 2024 Global, regional, and national burden of neck pain, 1990-2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021. The Lancet Rheumatology. 6:e142-e155.

[2] Chen L, Peng K, Huang H, Gong Z, Huang J, Mohamed A, Chen Q, Sow W, Guo L, Kwan K, Li B, Khan M , Makvnadi P , Jones M , Shen S, Wang X, Ma X, Li H, Wu A. 2024 Injectable Hydrogel Based on Enzymatic Initiation of Keratin Methacrylate for Controlled Exosome Release in Intervertebral Disc Degeneration Therapy. Advanced Functional Materials.34(32):2316545.

[3] Chen Q, Qian Q, Xu H, Zhou H, Chen L, Shao N, Zhang K, Chen T, Tian H, Zhang Z, Jones M, Kwan KYH, Sewell M, Shen S, Wang X, Khan MA, Makvandi P, Jin S, Zhou Y,Wu A. 2024 Mitochondrial-Targeted Metal-Phenolic Nanoparticles to Attenuate Intervertebral Disc Degeneration: Alleviating Oxidative Stress and Mitochondrial Dysfunction. ACS Nano. 18(12):8885-8905.

[4] Jin Y, Wu O, Chen Q, Chen L, Zhang Z, Tian H, Zhou H, Zhang K, Gao J, Wang X, Guo Z, Sun J, Kwan K, Jones M, Li Y, Zare E, Makvandi P, Wang X, Shen S, Wu A. 2024 Hypoxia-Preconditioned BMSC-Derived Exosomes Induce Mitophagy via the BNIP3-ANAX2 Axis to Alleviate Intervertebral Disc Degeneration. Advanced Science. Online DOI: 10.1002/advs.202404275.

[5] Chen T, Qian Q, Makvandi P, Zare EN, Chen Q, Chen L, Zhang Z, Zhou H, Zhou W, Wang H, Wang X, Chen Y, Zhou Y, Wu A. 2023 Engineered high-strength biohydrogel as a multifunctional platform to deliver nucleic acid for ameliorating intervertebral disc degeneration. Bioactive Materials 25:107-121.