Dr. Lei Zhang, MD, PhD

Position

· Chief Director, Master Supervisor, Associate Professor

· Department of Orthopaedics, The First Affiliated Hospital of Wenzhou Medical University

· Clinical Specialty: Arthroplasty, Sports Medicine

· Scientific Specialty: Tissue Engineering for Bone and Cartilage Repair

Education

· Bachelor's Degree: Zhejiang University

· Master's Degree: Zhejiang University

· Doctorate: Southern Medical University

Biography

Dr. Lei Zhang is a distinguished orthopaedic surgeon and researcher specializing in arthroplasty, sports medicine, and tissue engineering for bone and cartilage repair. With a career spanning clinical practice and academic research, he has made significant contributions to the field of orthopaedics, including advancements in 3D bioprinting and bioceramic scaffolds for bone repair. Dr. Zhang is actively involved in international collaborations and editorial boards of leading scientific journals. He is also a recognized mentor, guiding young researchers and medical professionals.

Professional Experience

· Fellowships:

2005.7-2005.8: Graz University, Austria

2010.6-2010.7: Singapore General Hospital

2011.6-2011.9: WaldKrankenhaus Hospital, Bonn, Germany

2014.4-2014.5: Peking University Third Hospital

2014.6-2014.7: JST Hospital

Memberships and Service

· Vice Director, Youth Committee of Sports Medicine Branch, Zhejiang Medicine Association

· Member, Youth Committee of Zhejiang Medicine Association

· Member, Group of Hip and Knee Preservation, Zhejiang Medical Doctor Association

· Member, Zhejiang Geriatrics Association

· Member, Orthopaedic Youth Doctor Alliance, Wu Jieping Medical Foundation

Editorial Appointments

· Chief Editor, Special Issues in Frontiers in Bioengineering and Biotechnology

· Youth Editorial Board, School of Medicine and Health Sciences

· Youth Editorial Board, Biomaterials Translational

Selected Publications

1. Ke X, Qiu J, Chen S, Sun X, Wu F, Yang G, Zhang L*. Concurrent Arthroscopic Meniscal Repair During Open-Wedge High Tibial Osteotomy Is Not Clinically Beneficial for Medial Meniscus Posterior Root Tears. Knee Surg Sports Traumatol Arthrosc. 2021;29(3):955-965.

2. Lin L#, Jiang S#, Yang S*, Yang G, Xie B*, Zhang L*. Identical Clinical Outcomes Between Neutral and Classic Targeted Alignments After High Tibial Osteotomy in Medial Meniscus Posterior Root Tear: A Prospective Randomized Study. Int Orthop. 2024;48(2):427–437.

3. Yue X#, Jiao X#, Xu C, Zhang Y, Wu F, Wang H, Zhu Q, Zhang Z, Zhao L, Sun X, Yang X, He F, Gou Z*, Yang G*, Zhang L*. 3D Printing Novel Porous Granule-Type Bioceramics via Magnesium Tuning Biological Performances Beneficial for Implantation and Clinical Translation. Chemical Engineering Journal. 2024;486:150401.

4. Jiao X#, Wu F#, Yue X, Yang J, Zhang Y, Qiu J, Ke X, Sun X, Zhao L, Xu C, Li Y, Yang X, Yang G, Gou Z*, Zhang L*. New Insight into Biodegradable Macropore Filler on Tuning Mechanical Properties and Bone Tissue Ingrowth in Sparingly Dissolvable Bioceramic Scaffolds. Mater Today Bio. 2023;24:100936.

5. Yue X#, Zhao L#, Yang J#, Jiao X, Wu F, Zhang Y, Li Y, Qiu J, Ke X, Sun X, Yang X, Gou Z*, Zhang L*, Yang G*. Comparison of Osteogenic Capability of 3D-Printed Bioceramic Scaffolds and Granules with Different Porosities for Clinical Translation. Front Bioeng Biotechnol. 2023;11:1260639.

6. Dai T#, Zhang L#, Ran Y#, Zhang M, Yang B, Lu H, Lin S*, Zhang L*, Zhou F*. MAVS deSUMOylation by SENP1 Inhibits Its Aggregation and Antagonizes IRF3 Activation. Nat Struct Mol Biol. 2023;30(6):785-799. doi: 10.1038/s41594-023-00988-8.

7. Lin L#, Jiang S#, Yang J, Qiu J, Jiao X, Yue X, Ke X, Yang G, Zhang L*. Application of 3D-Bioprinted Nanocellulose and Cellulose Derivative-Based Bio-Inks in Bone and Cartilage Tissue Engineering. Int J Bioprint. 2023;9(1):212-229.

8. Zhang L, Wu Z*, Lu H*. Topological-Operon Secret Behind the Long-Range Transcriptional Coupling. Signal Transduct Target Ther. 2022 Oct;7(1):366.

9. Zhou C#, Li L#, Jia X#, Zhang L*. Editorial: 3D-Printed Biomaterials in Osteochondral Repair. Front Bioeng Biotechnol. 2022;10:983945.

10. Wang B#, Zhang L#, Dai T#, Qin Z, Lu H, Zhang L*, Zhou F*. Liquid–Liquid Phase Separation in Human Health and Diseases. Signal Transduct Target Ther. 2021 Aug;6(1):290.

11. Sun X, Qiu J, Jiang S, Lin L, Yang J, Wu F, Lei Zhang L. Fully Arthroscopic Treatment of Medial Hoffa Fracture Associated with Anterior Cruciate Ligament Tear: Case Report and Surgical Technique. J Int Med Res. 2021 Dec;49(12):3000605211067684.

12. Qiu J, Ke X, Chen S, Zhao L, Wu F, Yang G, Zhang L*. Risk Factors for Iliopsoas Impingement After Total Hip Arthroplasty Using a Collared Femoral Prosthesis. J Orthop Surg Res. 2020;15:267.

13. Ke X, Qiu J, Wang X, Yang X, Shen J, Ye S, Yang G, Xu S, Bi Q, Gou Z*, Jia X*, Zhang L*. Modification of Pore-Wall in Direct Ink Writing Wollastonite Scaffolds Favorable for Tuning Biodegradation and Mechanical Stability and Enhancing Osteogenic Capability. FASEB J. 2020;34:5673-5687.

14. Qiu J, Sun X, Zhang W, Ke X, Yang G, Zhang L*. Effect of Topical Tranexamic Acid in Total Hip Arthroplasty Patients Who Receive Continuous Aspirin for Prevention of Cardiovascular or Cerebrovascular Events: A Prospective Randomized Study. Orthop Traumatol Surg Res. 2019 Nov;105(7):1327-1332.

15. Zhang L, Yang G, Johnson BN, Jia X*. Three-Dimensional (3D) Printed Scaffold and Material Selection for Bone Repair. Acta Biomater. 2019;15(84):16-33.

16. Chen W#, Ke X#, Wang X, Sun X, Wang J, Yang G, Xia H, Zhang L*. Prevalence and Risk Factors for Postoperative Delirium in Total Joint Arthroplasty Patients: A Prospective Study. Gen Hosp Psychiatry. 2017;46:55-61.

17. Yang G, Chen W, Tang X, Huang Y, Zhang L*. Feasibility and Safety of 2-Day Discharge After Fast-Track Total Hip Arthroplasty: A Chinese Experience. J Arthroplasty. 2016;31(8):1686-1692.

Invited Lectures

· 2024: “Digital Technology in HTO,” APKASS, Hainan, China

· 2024: “The Optimal Targeted Alignment in HTO,” Chinese Association of Sports Medicine, Beijing, China

· 2024: “The Neutral Alignment in HTO in the Treatment of MMPRT,” Chinese Association of Orthopaedic Surgeons, Nanjing, China

Scientific Research Projects

1. 2021-2023: Study on the osteogenic differentiation of bone marrow mesenchymal stem cells using ECM and bioceramic composite scaffolds derived from 3D bioprinting co-cultured cells. Zhejiang Provincial Natural Science Foundation.

2. 2020-2022: Design of coaxial printed shell mesoporous exosome/bioceramic composite scaffold and basic research on promoting the repair of infectious bone defects. Zhejiang Province Medical and Health Science and Technology Project.

Awards and Honors

· 2024: World’s Top 2% Scientists

· 2018: Zhejiang Province Health Innovation Talents

· 2017: 151 Talents of Zhejiang Province

· 2015: Rising Star in Medicine Field

Contact Information

· Address: Shangcai Village, Ouhai, Wenzhou, Zhejiang, China

· E-mail: zhanglei@wmu.edu.cn

· Phone: +86-13587557573

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