Prof. Ji Jiansong, MD, PhD

Position: President of The Fifth Affiliated Hospital of Wenzhou Medical University (Lishui Central Hospital, Lishui Hospital of Zhejiang University)

Professor of Zhejiang University, The Fifth Affiliated Hospital of Wenzhou Medical University, and The Clinical College of The Affiliated Central Hospital of Lishui University

Biography

Prof. Ji Jiansong is the Dean of The Fifth Affiliated Hospital of Wenzhou Medical University and a professor at Zhejiang University. With extensive experience in clinical practice and academic research, he has dedicated over 20 years to pioneering studies in imaging diagnosis and minimally invasive interventional treatment for various diseases, particularly tumor and vascular diseases. Prof. Ji’s research contributions include the development of international examination protocols and diagnostic criteria for acute and non-acute intestinal obstruction, as well as innovations in radiofrequency ablation following transarterial chemoembolization (TACE) for tumor treatment. His work focuses on improving patient survival rates, minimizing side effects of therapies, and advancing the field of precision medicine. Prof. Ji is a recognized leader in interventional medicine and has made significant contributions to medical science and technology in China.

Research Interests

· Imaging diagnosis of tumor and vascular diseases

· Minimally invasive interventional treatments

· Precision medicine in oncology

· Interventional radiology and therapy for gastrointestinal and liver cancers

· Development of novel therapeutic nanoparticles for cancer treatment

Selected Publications

1. Ji J., et al. "Ferritin-hijacking Nanoparticles Spatiotemporally Directing Endogenous Ferroptosis for Synergistic Anticancer Therapy." Advanced Materials, 2022.

2. Ji J., et al. "Feasibility of Intratumoral Radiofrequency Hyperthermia-enhanced Herpes Simplex Virus Thymidine Kinase Gene Therapy in Non-Small-Cell Lung Cancer." Radiology, 2018, 288(2): 612-620.

3. Ji J., et al. "Sialic Acid-engineered Mesoporous Polydopamine Nanoparticles for MRI-guided Combined Chemo-photothermal Treatment of Hepatic Cancer." Bioactive Materials, 2021, 6(5): 1423-1435.

4. Ji J., et al. "Multiple Immunomodulatory Strategies Based on Targeted Regulation of Proprotein Convertase Subtilisin/Kexin Type 9 and Immune Homeostasis against Hepatocellular Carcinoma." ACS Nano, 2024, 18(12): 8811-8826.

5. Tang B., Zhu J., Wang Y., et al. "Targeted xCT-mediated Ferroptosis and Protumoral Polarization of Macrophages Is Effective against HCC and Enhances the Efficacy of the Anti-PD-1/L1 Response." Advanced Science, 2023, 10(2): e2203973.

6. Chen M., Shu G., Xu X., et al. "HIF-2α-targeted Interventional Chemoembolization Multifunctional Microspheres for Effective Elimination of Hepatocellular Carcinoma." Biomaterials, 2022, 284: 121512.

7. Chen W., Zou P., Zhao Z., et al. "Synergistic Antitumor Activity of Rapamycin and EF24 via Increasing ROS for the Treatment of Gastric Cancer." Redox Biology, 2016, 10: 78-89.

8. Zhao Z., Song J., Tang B., et al. "CircSOD2 Induced Epigenetic Alteration Drives Hepatocellular Carcinoma Progression through Activating JAK2/STAT3 Signaling Pathway." Journal of Experimental & Clinical Cancer Research, 2020, 39(1): 259.

9. Chen M., Wu L., Tu J., et al. "miR-590-5p Suppresses Hepatocellular Carcinoma Chemoresistance by Targeting YAP1 Expression." EBioMedicine, 2018, 35: 142-154.

10. Tang B., Zhu J., Zhao Z., et al. "Diagnosis and Prognosis Models for Hepatocellular Carcinoma Patient’s Management Based on Tumor Mutation Burden." Journal of Advanced Research, 2021, 33: 153-165.

Teaching

Prof. Ji teaches and supervises doctoral and postdoctoral students at Zhejiang University, Wenzhou Medical University, and several other institutions, focusing on interventional medicine, imaging techniques, and precision treatments for oncology. He also supervises research projects and clinical trials related to cancer therapy and medical innovation.

Major Scientific Research Achievements

· Chief Scientist of National Key Research and Development Program (2020-2022)

· National Natural Science Foundation of China (2021-2024)

· Key Research Plan of Zhejiang Provincial Research Projects (2018-2020)

· Leading talent in China’s National Natural Science Foundation (2016-2019)

· Pioneer and Leading Goose R&D Program of Zhejiang (2023-2025)

· Patents: 15 invention patents and 23 utility models, including innovative methods and systems for cancer treatment and diagnosis.

Awards and Honors

· National Advanced Worker

· Selected for the National Millions of Talents Project

· Zhejiang Province "Ten Thousand Talents Plan" Leading Talent

· Zhejiang Provincial Science and Technology Progress Award (multiple prizes)

· First China Outstanding Youth Contribution Award in Integrated Traditional Chinese and Western Medicine

· Zhejiang Provincial Model Worker and Zhejiang Provincial Youth Medal

· Zhejiang Provincial University Leading Talent

Monographs

· "The Practical X-ray Diagnostic Manual" (Chief Editor, 2022)

· "The Practical MR Diagnostic Manual" (Chief Editor, 2022)

· "CT Diagnosis and Interventional Treatment of Pulmonary Tubercles" (Chief Editor, 2021)

· "Imaging-guided Tumor Treatment: A Multidisciplinary Treatment Method" (Editor, 2018)

Professional Affiliations

· Chairman, Interventional Medical Engineering and Biotechnology Committee, Chinese Medical Doctor Association

· Standing Committee, Oncology Interventional Professional Committee, Chinese Anti-Cancer Association

· President, Interventional Physician Branch, Zhejiang Medical Association

· Editorial Board Member, Asian Journal of Pharmaceutical Sciences, Military Medical Research, Chinese Medical Journal

· Reviewer, The Lancet Gastroenterology & Hepatology, Journal of Hepatology, European Radiology

Contact Information

For more information or to schedule an appointment, please contact Prof. Ji via [Email Address] or visit [Institution’s Website] for office hours and consultation details.