学院（School）: The 1st School of Medicine

专业（Discipline）: Neurology

研究方向（Research Interests）:

1. Neurodegeneration diseases

2.Alzheimer disease

3.Parkinson disease

邮箱（Email）:

xiechenglong1987@126.com

个人简历（Biography）

教育背景(Educational Background)

2005.09-2010.07 Bachelor of Medicine (MBBS), Wenzhou Medical college, China

2010.09-2013.07 Master of Medicine, Department of Neurology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, China

2013.09-2016.07 Doctor of Medicine (MD), Department of Neurology, Xinhua Hospital affiliated to the Medical School of Shanghai Jiaotong University, China

2019.09-2021.12 Postdoctoral Visiting Fellow, Department of Clinical Molecular Biology University of Oslo and Akershus hospital (Advisor: Dr. Evandro Fei Fang), Norway.

工作经历(Working Experience)

2018.01~2020.12 Attending physician

Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University

2016.08~2017.12 Resident doctor

Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University

2021.01~present Associate chief physician

Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University

学术兼职(Part-time Academic Jobs)

1. Member of the Brain Cognition and Health Branch of the Chinese Gerontological Society and the Chinese Society of Geriatrics (中国老年学会和老年医学学会“脑认知与健康分会”委员)

2. Member of the "Parkinson's Disease and Movement Disorders" Study Group of the Neurology Division of the Zhejiang Medical Association (浙江省医师协会神经内科会分“帕金森病与运动障碍”学组委员)

3. Member of the "Cognitive and Neuropsychological" group of the Neurology Department of the Zhejiang Medical Association(浙江省医学会神经内科会分“认知与神经心理”学组委员)

所获荣誉(Awards)

1. Zhejiang Province Colleges and Universities Leading Talent Training Program - Young Talents (浙江省高校领军人才培养计划-青年优秀人才)

2. Zhejiang Province High-level Talent Special Support Program Medical and Health Youth Talent (浙江省高层次人才特殊支持计划医疗卫生青年人才)

发表文章（Representative Publication）

1. Xie CL^#, Zhuang XX^#, Niu Z, Ai R^#, Lautrup S^#, Zheng S, Jiang Y, Han R, Gupta TS, Cao S, Lagartos-Donate MJ, Cai CZ, Xie LM, Caponio D, Wang WW, Schmauck-Medina T, Zhang J, Wang HL, Lou G, Xiao X, Zheng W, Palikaras K, Yang G, Caldwell KA, Caldwell GA, Shen HM, Nilsen H, Lu JH*, Fang EF*. Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow. Nat Biomed Eng. 2022 Jan;6(1):76-93.

2. Xi Xiong, Jialong Hou, Yi Zheng, Tao Jiang, Xuemiao Zhao, Jinlai Cai, Jiani Huang, Haijun He, Jiaxue Xu, Shuangjie Qian, Yao Lu, XinShi Wang, Wenwen Wang, Qianqian Ye, Shuoting Zhou, Mengjia Lian, Jian Xiao*, Weihong Song*, Xie CL*. NAD+-boosting agent nicotinamide mononucleotide potently improves mitochondria stress response in Alzheimer’s disease via ATF4-dependent mitochondrial UPR. Cell Death & Disease. 2024. Oct 11;15(10):744.

3. Qian S^#, He H^#, Xiong X, Ai R, Wang W, Zhu H, Ye Q, Zhou S, Nilsen H*, Xie CL*. Identification of mitophagy-associated proteins profile as potential plasma biomarkers of idiopathic Parkinson's disease. CNS Neurosci Ther. 2024 Apr;30(4):e14532.

4. Xiong X, He H, Ye Q, Qian S, Zhou S, Feng F, Fang EF*, Xie CL*. Alzheimer's disease diagnostic accuracy by fluid and neuroimaging ATN framework. CNS Neurosci Ther. 2024 Feb;30(2):e14357.

5. Wang XS^#, Zhang ZR^#, Zhang XR, Chen SY, Shao B*, Xie CL*. Modulation of CaMKIIa-GluN2B interaction in levodopa-induced dyskinesia in 6-OHDA-lesioned Parkinson's rats. Biomed Pharmacother. 2018 Aug 21;107:769-776.

6. Chen J^#, He HJ^#, Ye Q, Feng F, Wang WW, Gu Y, Han R*, Xie CL*. Defective Autophagy and Mitophagy in Alzheimer's Disease: Mechanisms and Translational Implications. Mol Neurobiol. 2021 Oct;58(10):5289-5302.

7. Qian S^#, Zheng Y^#, Jiang T, Hou J, Cao R, Cai J, Ma E, Wang W, Song W*, Xie CL*. A risk variant rs6922617 in TREM is discrepantly associated with defining neuropathological hallmarks in the Alzheimer's continuum. J Gerontol A Biol Sci Med Sci. 2024 Jul 25:glae185.

8. Wang W^#, Huang J^#, Qian S, Zheng Y, Yu X, Jiang T, Ai R, Hou J, Ma E, Cai J, He H, Wang X*, Xie CL*. Amyloid-β but not tau accumulation is strongly associated with longitudinal cognitive decline. CNS Neurosci Ther. 2024 Jul;30(7):e14860.

9. Wang WW^#, Han R^#, He HJ, Wang Z, Luan XQ, Li J, Feng L, Chen SY, Aman Y*, Xie CL*. Delineating the Role of Mitophagy Inducers for Alzheimer Disease Patients. Aging Dis. 2021 Jun 1;12(3):852-867.

10. Feng L^#, He H^#, Xiong X, Xia K, Qian S, Ye Q, Feng F, Zhou S, Hong X, Liu Y*, Xie CL*. Plasma-derived phosphoglycerate mutase 5 as a biomarker for Parkinson's disease. Front Aging Neurosci. 2022 Oct 28;14:1022274.

11. Zhao X^#, He H^#, Xiong X, Ye Q, Feng F, Zhou S, Chen W, Xia K, Qian S, Yang Y*, Xie CL*. Lewy Body-Associated Proteins A-Synuclein (a-syn) as a Plasma-Based Biomarker for Parkinson's Disease. Front Aging Neurosci. 2022 May 12;14:869797.

12. He HJ^#, Xiong X^#, Zhou S, Zhang XR, Zhao X, Chen L*, Xie CL*. Neuroprotective effects of curcumin via autophagy induction in 6-hydroxydopamine Parkinson's models. Neurochem Int. 2022 Feb 2:105297.

13. Wang X^#, He HJ^#, Xiong X, Zhou S, Wang WW, Feng L, Han R*, Xie CL*. NAD+ in Alzheimer's Disease: Molecular Mechanisms and Systematic Therapeutic Evidence Obtained in vivo. Front Cell Dev Biol. 2021 Aug 3;9:668491.

14. Zhang XR^#, Jiang ZY^#, Zhang ZR, Chen HJ, Wu K, He JC*, Xie CL*. The Advantages of Levodopa-Carbidopa Intestinal Gel for Patients with Advanced Parkinson's Disease: A Systematic Review. Drug Des Devel Ther. 2020;14:845-854.

15. Zhang ZR^#, Zhang XR^#, Luan XQ, Wang XS, Wang WW, Wang XY, Shao B*, Xie CL*. Striatal overexpression of β-arrestin2 counteracts L-dopa-induced dyskinesia in 6-hydroxydopamine lesioned Parkinson's disease rats. Neurochem Int. 2019 Dec;131:104543.

16. Wang WW^#, Zhang XR^#, Lin JY, Zhang ZR, Wang Z, Chen SY*, Xie CL*. Levodopa/Benserazide PLGA Microsphere Prevents L-Dopa-Induced Dyskinesia via Lower β-Arrestin2 in 6-Hydroxydopamine Parkinson's Rats. Front Pharmacol. 2019 Jun 14;10:660.

17. Chen SY^#, Zhang XR, Chen J, Ge WQ, Wang WW, Wang XS*, Xie CL*. An Overview of Meta-Analyses of Endovascular Bridging Therapies for Acute Ischemic Stroke. Biomed Res Int. 2018 Mar 7;2018:9831210.

18. Zhu ZG^#, Sun MX^#, Zhang WL, Wang WW, Jin YM*, Xie CL*. The efficacy and safety of coenzyme Q10 in Parkinson's disease: a meta-analysis of randomized controlled trials. Neurol Sci. 2017 Feb;38(2):215-224.

19. Wang WW^#, Wang XS^#, Zhang ZR, He JC*, Xie CL*, A Meta-Analysis of Folic Acid in Combination with Anti-Hypertension Drugs in Patients with Hypertension and Hyperhomocysteinemia, Front Pharmacol, 2017, 8:585.

20. Wang XS^#, Zhang ZR^#, Zhang MM, Sun MX, Wang WW*, Xie CL*, Neuroprotective properties of curcumin in toxin-base animal models of Parkinson's disease: a systematic experiment literatures review, BMC Complement Altern Med, 2017, 17,17(1):412.