Dr. Baohua Liu, MD, PhD

Position:

· Vice Dean, Rehabilitation Medicine College, Wenzhou Medical University (01.2024–present)

· Chief Physician and Chief of Department, Neurorehabilitation Department, The 2nd Affiliated Hospital of Wenzhou Medical University (12.2022–present)

· Associate Chief Physician and Chief of Department, Neurorehabilitation Department, The 2nd Affiliated Hospital of Wenzhou Medical University (12.2014–12.2022)

· Associate Chief Physician and Deputy of Department, Neurorehabilitation Department, The 2nd Affiliated Hospital of Wenzhou Medical University (08.2012–11.2014)

· Attending Physician, Neurorehabilitation Department, The 2nd Affiliated Hospital of Wenzhou Medical University (01.2006–07.2012)

· Physician, Neurorehabilitation Department, The 2nd Affiliated Hospital of Wenzhou Medical University (08.2003–12.2006)

Institution:

· The 2nd Affiliated Hospital of Wenzhou Medical University

Education:

· M.D. (2012): Neurology, Jilin University, China

· Master Degree (2003): Neurology, Shaanxi University of Chinese Medicine, China

· Bachelor Degree (2000): Acupuncture and Moxibustion and Tuina of Chinese Medicine, Shaanxi University of Chinese Medicine, China

Biography:

Dr. Baohua Liu is a prominent figure in neurorehabilitation and currently serves as the Vice Dean of the Rehabilitation Medicine College at Wenzhou Medical University. He is also the Chief Physician and Chief of the Neurorehabilitation Department at The 2nd Affiliated Hospital of Wenzhou Medical University. Dr. Liu has a rich educational background with an M.D. in Neurology from Jilin University, a Master's degree in Neurology, and a Bachelor's degree in Acupuncture and Moxibustion and Tuina of Chinese Medicine from Shaanxi University of Chinese Medicine.

Throughout his career, Dr. Liu has published numerous peer-reviewed papers and book chapters, led significant research projects, and holds several patents. His research focuses on the pathophysiological mechanisms and intervention treatments of traumatic/ischemic optic neuropathy and eye tumors. Dr. Liu is dedicated to advancing the field of neurorehabilitation through both clinical practice and research.

Research Interests:

· Pathophysiological mechanisms and intervention treatments of traumatic/ischemic optic neuropathy and eye tumors

Peer-Reviewed Papers:

1. Liu B, Dong J, Lu L, Sha Y, Song L, Liu Q. Recombinant human granulocyte-colony stimulating factor and differential expression of cerebral cortical proteins in the subacute stage of cerebral ischemia/reperfusion. Neural Regen Res. 2011;6(19):1478-1483.

2. Liu B, Hu B, Shao S, Wu W, Fan L, Bai G, Shang P, Wang X. CD163/Hemoglobin Oxygenase-1 Pathway Regulates Inflammation in Hematoma Surrounding Tissues after Intracerebral Hemorrhage. Stroke and Cerebrovascular Diseases. 2015;24(12):2800-2809.

3. Shang P, He Z, Chen J, Huang S, Liu B, Liu H, Wang X. Absence of the Adenosine A2A Receptor Confers Pulmonary Arterial Hypertension Through RhoA/ROCK Signaling Pathway in Mice. Cardiovascular Pharmacology. 2015;66(6):569-75.

4. Hu B, Chen S, Zou M, He Z, Shao S, Liu B. Effect of Extracellular Vesicles on Neural Functional Recovery and Immunologic Suppression after Rat Cerebral Apoplexy. Cell Physiol Biochem. 2016;40(1-2):155-162.

5. Hu B, Hou W, Li X, Ma L, Bai X, Liu Q, Liu B. Aster tataricus attenuates the neuronal cell damage and restores the cognitive functions in epileptic rat. Biomedical Research- India. 2017;28(3):1189-1194.

6. Xue Y, Wang X, Thapa S, Wang L, Wang J, Xu Z, Wu S, Tao L, Wang G, Qian L, Liao L, Liu B, Ji K. Very early recurrence predicts long-term outcome in patients after atrial fibrillation catheter ablation: a prospective study. BMC Cardiovascular Disorders. 2017;17(1):109-115.

7. Wu W, Liu B, Xie C, Xia X, Zhang Y. Neuroprotective effects of N-acetyl cysteine on primary hippocampus neurons against hydrogen peroxide-induced injury are mediated via inhibition of mitogen-activated protein kinases signal transduction and antioxidative action. Molecular Medicine Reports. 2018;17(5):6647-6654.

8. Jiang S, Xiang J, Gao X, Guo K, Liu B. The comparison of telerehabilitation and face-to-face rehabilitation after total knee arthroplasty: A systematic review and meta-analysis. Telemed Telecare. 2018;24(4):257-262.

9. Kong H, Chen H, Fu Y, Dong Y, Liu B. The therapeutic effect and mechanism of dl-3-n-butylphthalide in Alzheimer’s disease. Int J Clin Exp Med. 2020;13(10):7552-7558.

10. Chen W, Chen M, Jin S, Li S, Pan C, Liu B. Effects of Nano-Sulfides on Learning and Memory Abilities and Expression of Related Genes in Cyclic Adenosine Monophosphate-cAMP Response Element Binding-Brain-Derived Neurotrophic Factor Pathway in Rats. Nanoscience and Nanotechnology. 2021;21(2):1142-1147.

11. Liu B, Ruan J, Chen M, Li Z, Manjengwa G, Schlüter D, Song W, Wang X. Deubiquitinating enzymes (DUBs): decipher underlying basis of neurodegenerative diseases. Mol Psychiatry. 2022;27(1):259-268.

12. Lu C, Jin L, Bi J, Jin H, You X, Peng L, Fan H, Wang H, Wang L, Fan Z, Wang X, Liu B. Toxicokinetics of recombinant human fibroblast growth factor 21 for injection in cynomolgus monkey for 3 months. Front Pharmacol. 2023;14:1176136.

13. Li Z, Liu B, Lambertsen KL, Clausen BH, Zhu Z, Du X, Xu Y, Poulsen FR, Halle B, Bonde C, Chen M, Wang X, Schlüter D, Huang J, Waisman A, Song W, Wang X. USP25 Inhibits Neuroinflammatory Responses After Cerebral Ischemic Stroke by Deubiquitinating TAB2. Adv Sci. 2023;10(28):e2301641.

14. Liu B, Miao X, Shen J, Lou L, Chen K, Mei F, Chen M, Su X, Du X, Zhu Z, Song W, Wang X. USP25 ameliorates diabetic nephropathy by inhibiting TRAF6-mediated inflammatory responses. Int Immunopharmacol. 2023;124:110877.

Non-Peer Reviewed Publications:

1. Book Chapters: Peripheral neuropathy. New Neurology. ISBN 978-7-5587-2255-4. (2019)432-458.

2. Book Chapters: Diseases of Qi, blood and body fluid; Diseases of meridians and limbs. Essentials of TCM Diagnosis and Treatment. ISBN 978-7-5189-0044-2. (2015)221-239.

3. Book Chapters: Rheumatism and connective tissue disease, Diseases of meridians and limbs. TCM Diagnosis and Treatment and Rehabilitation. ISBN 978-7-5364-9850-1. (2020)137-145.

Research Projects:

1. The core talent plan of the Zhejiang Medical Platform Project (grant no. 2013RCA036).

2. The public welfare project of Science and Technology Department of Zhejiang Province (grant no. 2017C33027).

3. Zhejiang Province Basic Public Welfare Research Project (grant no. LGD22H090013).

4. Zhejiang Province Medical and Health Science and Technology Plan Project (grant no. 2023KY150).

Invention Patent:

· Lower limb exercise rehabilitation device, Liu Baohua, ZL 2020 1 0520365.2, Invention Patent: CN 111643810 B, The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, May 12, 2023

Professional Licenses and Certifications:

· Certificate of Associate Professor of Medicine Qualification, P.R. China: The license number is G3300238880.

· Certificate of Medical Doctor Qualification, P.R. China (2011): The certificate number is 201122110610402197611150359.

Contact:

· Email: bhbh369@sina.com