Dr. Ying Zhou, PhD

Position:

· Director, Quality Management Department, The First Affiliated Hospital of Wenzhou Medical University (2024 - present)

· Associate Chief Physician in Nephrology, Deputy Head of Nephrology Department, Associate Professor, Master’s Tutor, The First Affiliated Hospital of Wenzhou Medical University (2019 - present)

Institution:

· The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou

Education:

· 2023 - 2024: Visiting Scholar, Houston University, USA

· 2014 - 2017: PhD in Internal Medicine, Sun Yat-sen University

· 2006 - 2009: Master in Internal Medicine, Wenzhou Medical University

· 2000 - 2005: Bachelor in Clinical Medicine, Wenzhou Medical University

Work Experience:

· 2024 - Present: Director, Quality Management Department, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou

· 2019 - Present: Associate Chief Physician in Nephrology, Deputy Head of Nephrology Department, Associate Professor, Master’s Tutor, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou

· 2017 - 2019: Attending Doctor in Nephrology, Teaching Secretary of Nephrology Department, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou

· 2012 - 2014: Attending Doctor in Nephrology, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou

· 2009 - 2012: Resident Doctor in Nephrology, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou

Publications:

1. Ying Y, Wang L, Ma S, Zhu Y, Ye S, Jiang N, Zhao Z, Zheng C, Shentu Y, Wang Y, Li D, Zhang J, Chen C, Huang L, Yang D, Zhou Y*. An enhanced machine learning approach for effective prediction of IgA nephropathy patients with severe proteinuria based on clinical data. Comput. Biol. Med. 2024;173:108341.

2. Bu S, Zheng H, Chen S, Wu Y, He C, Yang D, Wu C, Zhou Y*. An optimized machine learning model for predicting hospitalization for COVID-19 infection in the maintenance dialysis population. Comput. Biol. Med. 2023;165:107410.

3. Zhou Y, Liu X, Ma S, Zhang N, Yang D, Wang L, Ye S, Zhang Q, Ruan J, Ma J, Wang S, Jiang N, Zhao Z, Zhao S, Zheng C, Fan X, Gong Y, Abdoul RM, Hu W, Pan J, Wang X, Fan J, Li J, Liu R, Shentu Y. ChK1 activation induces reactive astrogliosis through CIP2A/PP2A/STAT3 pathway in Alzheimer's disease. FASEB J. 2022;36:e22209.

4. Shentu Y, Li Y, Xie S, Jiang H, Sun S, Lin R, Chen C, Bai Y, Zhang Y, Zheng C, Zhou Y*. Empagliflozin, a sodium glucose cotransporter-2 inhibitor, ameliorates peritoneal fibrosis via suppressing TGF-β/Smad signaling. Int. Immunopharmacol. 2021;93:107374.

5. Zhou Y, Yang D, Chen H, Zheng C, Jiang H, Liu X, Huang X, Ye S, Song S, Jiang N, Zhao Z, Ma S, Ma J, Huang K, Chen C, Fan X, Gong Y, Wang X, Fan J, Liu R, Shentu Y. Polyphyllin I attenuates cognitive impairments and reduces AD-like pathology through CIP2A-PP2A signaling pathway in 3XTg-AD mice. FASEB J. 2020;34:16414-16431.

6. Zhou Y, Tian Q, Zheng C, Yang J, Fan J, Shentu Y. Myocardial infarction-induced anxiety-like behavior is associated with epigenetic alterations in the hippocampus of rat. 2020.

7. Shentu Y, Jiang H, Liu X, Chen H, Yang D, Zhang J, Cheng C, Zheng Y, Zhang Y, Chen C, Zheng C, Zhou Y*. Nestin Promotes Peritoneal Fibrosis by Protecting HIF1-α From Proteasomal Degradation. Front Physiol. 2020;11:517912.

8. Zheng C, Xu J, Chen C, Lin F, Shao R, Lin Z, Liu Y, Zhou Y*. Effects of sleep disorders and sedative-hypnotic medications on health-related quality of life in dialysis patients. Int. Urol. Nephrol. 2019;51:163-174.

9. Zheng C, Zhang J, Chen X, Zhang J, Ding X, You X, Fan L, Chen C, Zhou Y*. MicroRNA-155 Mediates Obesity-Induced Renal Inflammation and Dysfunction. Inflammation. 2019;42:994-1003.

10. Zhou Y, Fan J, Zheng C, Yin P, Wu H, Li X, Luo N, Yu X, Chen C. SGLT-2 inhibitors reduce glucose absorption from peritoneal dialysis solution by suppressing the activity of SGLT-2. Biomed. Pharmacother. 2019;109:1327-1338.

11. Zhou Y, Yin P, Li B, Li J, Huang N, Wu H, Ullah H, Yang X, Yu X. Effect of Sedative-Hypnotic Medicines on Mortality in Peritoneal Dialysis Patients with Sleep Disorders: A Retrospective Cohort Study. Blood Purif. 2017;45:95-101.

Patents:

1. Zhou Ying, Chen Chaosheng, Zheng Chenfei, Zhang Jianna, Su Bofeng, Fan Jinjin, Wu Haishan, Yin Peiran, Guo Lin. Application of SGLT2 inhibitor in the preparation of reagents for inhibiting the absorption of glucose by PMCs or peritoneal fibrosis. ZL 2018 1 0521509.9.

Research Projects:

1. Zhejiang Natural Science Foundation Committee, Natural Science Foundation Exploration Project, LTGY23H050003. Research on the Treatment of Peritoneal Fibrosis by Using Alginate Targeted Microcapsules Loaded with PMCs Modified by Aptamer TGF-β1. 2023 - 2025, 100,000 yuan. Principal Investigator.

2. Zhejiang Natural Science Foundation Committee, Youth Project, LQ19H050002. Research on the Inhibition of Peritoneal Dialysis-related Peritoneal Fibrosis by Sodium-glucose Cotransporter 2 Inhibitors through the Inhibition of the TGF-β/Smad Pathway. 2019 - 2021, 90,000 yuan. Principal Investigator.

3. Wenzhou Science and Technology Commission, Basic Scientific Research Project, Y2020024. Mechanism Study on Neuronal TLR4 Signaling Pathway Activation Leading to Apoptosis Involved in the Occurrence of Cognitive Dysfunction in Uremia. 2021 - 2023, 30,000 yuan. Principal Investigator.

4. Wenzhou Science and Technology Commission, Basic Scientific Research Project, Y20180159. Research on the Inhibition of Peritoneal Dialysis-related Peritoneal Fibrosis by Sodium/glucose Cotransporter 2 Inhibitors through the Inhibition of the TGF-β/Smad Pathway. 2019 - 2021, 20,000 yuan. Principal Investigator.

5. Wenzhou Science and Technology Commission, Basic Scientific Research Project, Y20110129. The Role of Warfarin in Preventing Long-term Indwelling Catheter Dysfunction in Maintenance Hemodialysis Patients. 2012 - 2015. Self-financed. Principal Investigator.

Awards, Interests, Skills, and Community Involvement:

1. Deputy Chairman of Youth Committee of Renal Disease Branch of Zhejiang Medical Association

2. Vice Chairman of the Youth Committee of the Kidney Disease Branch of the Zhejiang Mathematical Medicine Society

3. Member of Renal Disease Branch of Wenzhou Medical Association

4. College English Test (Band 6) in 2005

Contact Information:

· E-mail: zhouying610@163.com

· Mobile Phone: +86-13626530377