学院（School）:第一临床医学院（The 1st School of Medicine）

专业（Discipline）:临床检验诊断学（Clinical Laboratory Diagnostics）

研究方向（Research Interests）:

1.肿瘤免疫学（Tumor immunology）; 2.血液病诊断（Diagnosis of hematological diseases）; 3.肿瘤分子生物学（Tumor molecular biology）

邮箱（Email）:

zhangshenghui

@wmu.edu.cn

个人简历（Biography）

教育背景(Educational Background)

2011.09-2014.06，复旦大学生物化学与分子生物学专业（Fudan University, Biochemistry and Molecular Biology），PhD

2005.09-2008.06, 温州医学院临床检验诊断学专业（Wenzhou Medical University, Clinical Laboratory Diagnostics），M.S

1996.09-2001.06, 温州医学院医学检验专业（Wenzhou Medical University, Medical Laboratory），M.D

工作经历(Working Experience)

2001.08-至今，温州医科大学附属第一医院（The First Affiliated Hospital of Wenzhou Medical University）

学术兼职(Part-time Academic Jobs)

浙江省实验动物行业协会理事（Member of Laboratory Animal Association of Zhejiang Province），浙江省医学会血液病专委会青委（Youth Member of Hematology Branch of Zhejiang Medical Association）。

所获荣誉(Awards)

无

发表文章（Representative Publication）

1. Chen C^#, Zhu Y^#, Li Q, Yu Z, Tan Y, Li F, Chen X, Jiang S, Yu K^*, Zhang S^*. SKI-606, a Src inhibitor, ameliorates benzene-induced hematotoxicity via blocking ROS/Src kinase-mediated p38 and Akt signaling pathways. Ecotoxicol Environ Saf, 2024, 286:117223. doi: 10.1016/j.ecoenv.2024.117223.

2. Li X^#, Zhou J^#, Ling Y, Tan Y, Zhang J, Wang X, Li F, Jiang S, Zhang S^*, Yu K^*, Han Y^*. Matrine induces autophagic cell death by triggering ROS/AMPK/mTOR axis and apoptosis in multiple myeloma. Biomed Pharmacother, 2024,175:116738. doi: 10.1016/j.biopha.2024.116738.

3. Huang Z^#, Zhou J^#, Jiang Y, Han Y, Wang X, Li F, Jiang S, Yu K^*, Zhang S^*. Combined inhibition of XIAP and autophagy induces apoptosis and differentiation in acute myeloid leukaemia. J Cell Mol Med, 2023, 27(12):1682-1696. doi: 10.1111/jcmm.17765.

4. Li F^#, Han Y^#, Chen R^#, Jiang Y, Chen C, Wang X, Zhou J, Xu Q, Jiang S, Zhang S, Yu K^*, Zhang S^*. MicroRNA-143 acts as a tumor suppressor through Musashi-2/DLL1/Notch1 and Musashi-2/Snail1/MMPs axes in acute myeloid leukemia. J Transl Med, 2023, 21(1):309. doi: 10.1186/s12967-023-04106-6.

5. Dong Y^#, Han Y^#, Huang Y^#, Jiang S, Huang Z, Chen R, Yu Z, Yu K^*, Zhang S^*. PD-L1 Is Expressed and Promotes the Expansion of Regulatory T Cells in Acute Myeloid Leukemia. Front Immunol, 2020,11:1710. doi: 10.3389/fimmu.2020.01710.

6. Qian S^#, Han Y^#, Shi Y^#, Xu W, Zhu Y, Jiang S, Chen Y, Yu Z, Zhang S, Yang Y, Yu K^*,Zhang S^*. Benzene induces haematotoxicity by promoting deacetylation and autophagy. J Cell Mol Med, 2019,23(2):1022-1033. doi: 10.1111/jcmm.14003.

7.Ma R, Zhang Y, Wang W, Wu J, Yang Q, Xu W, Jiang S, Han Y, Yu K^*, Zhang S^*. Inhibition of autophagy enhances the antitumour activity of tigecycline in multiple myeloma. J Cell Mol Med, 2018, 22(12):5955-5963. doi: 10.1111/jcmm.13865.

8.Han Y^#, Dong Y^#, Yang Q, Xu W, Jiang S, Yu Z, Yu K^*, Zhang S^*. Acute Myeloid Leukemia Cells Express ICOS Ligand to Promote the Expansion of Regulatory T Cells. Front Immunol, 2018,9:2227. doi: 10.3389/fimmu.2018.02227.